Multiple Brain Effects of Pridopidine in Huntington Disease Patients and Healthy Volunteers - A Simultaneous Sigma-1 Receptor PET/MRI Study

336 null Introduction: null null Huntington disease (HD) is a devastating inherited neurodegenerative disorder. Pridopidine is currently under development as a drug to maintain functional capacity or to provide functional benefit in HD. Its pharmacological effect is mainly mediated via sigma-1 receptor (S1R) interaction. Our knowledge on how this interaction exerts different brain processes in vivo, however, is limited so far. It was, thus, the...