Comparison of Amyloid in Cerebrospinal Fluid, Brain Imaging, and Autopsy in a Case of Progressive Supranuclear Palsy

Cerebrospinal fluid (CSF) amyloid-beta 1-42 (Aβ 1-42 ) and amyloid positron emission tomography (PET) are the 2 main Alzheimer disease amyloid biomarkers that have been validated in neuropathologically confirmed Alzheimer disease cases. Although many studies have shown concordance of amyloid positivity or negativity between CSF Aβ 1-42 and amyloid PET, several studies also reported discrepancies between these 2 Aβ biomarkers. We conducted a...