IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival
Abstract
In the tumor microenvironment, local immune dysregulation is driven in part by macrophages and dendritic cells that are polarized to a mixed proinflammatory/immune-suppressive phenotype. The unfolded protein response (UPR) is emerging as the possible origin of these events. Here we report that the inositol-requiring enzyme 1 (IRE1α) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the...
Paper Details
Title
IRE1α regulates macrophage polarization, PD-L1 expression, and tumor survival
Published Date
Jun 10, 2020
Journal
Volume
18
Issue
6
Pages
e3000687 - e3000687
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