Chondrodysplasias and Aneurysmal Thoracic Aortopathy: An Emerging Tale of Molecular Intersection

Genetic and pathomechanistic overlap exists between aneurysmal thoracic aortopathy and chondrodysplasias. Dysregulated TGF-β superfamily signaling, altered extracellular matrix organization, and endoplasmic reticulum stress emerge as shared disease processes. Therapeutic options for aneurysmal thoracic aortopathy might prove beneficial in chondrodysplasia patients and vice versa. Although at first glance chondrodysplasia and aneurysmal thoracic...