Reciprocal interaction between striatal cholinergic and low‐threshold spiking interneurons — A computational study

The striatum is the main input stage of the basal ganglia receiving extrinsic input from cortex and thalamus. The striatal projection neurons (SPN) constitute 95% of the neurons in the striatum in mice while the remaining 5% are cholinergic and GABAergic interneurons. The cholinergic (ChIN) and low‐threshold spiking interneurons (LTS) are spontaneously active and form a striatal subnetwork involved in salience detection and goal‐directed...