Decidual glycodelin-A polarizes human monocytes towards a decidual macrophage-like phenotype via siglec-7

Decidual macrophages constitute 20–30% of the total leukocytes in the pregnant uterus, which regulates maternal immune tolerance and placenta development. Abnormal number or activities of decidual macrophages are associated with fetal loss and pregnancy complications such as preeclampsia. Monocytes differentiate into decidual macrophages in a decidua-specific microenvironment. Despite their important roles in pregnancy, the factors regulating...