Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome
Abstract
Inflammasomes are multiprotein complexes of the innate immune system that orchestrate development of inflammation by activating the secretion of proinflammatory cytokines, IL-1β and IL-18. The LPS of Gram-negative bacteria have been shown to activate a novel, noncanonical inflammasome by directly binding in the cytosol to human caspase-4 and mouse caspase-11. Activation of noncanonical inflammasome exerts two major effects: it activates the...
Paper Details
Title
Function and Regulation of Noncanonical Caspase-4/5/11 Inflammasome
Published Date
Jun 15, 2020
Journal
Volume
204
Issue
12
Pages
3063 - 3069
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