Chase Dosing of Lipid Formulations to Enhance Oral Bioavailability of Nilotinib in Rats

Lipid-based formulations (LBF) have shown oral bioavailability enhancement of lipophilic drugs, but not necessarily in the case of hydrophobic drugs. This study explored the potential of lipid vehicles to improve the bioavailability of the hydrophobic drug nilotinib comparing a chase dosing approach and lipid suspensions.Nilotinib in vivo bioavailability in rats was determined after administering an aqueous suspension chase dosed with blank...