Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Late in Infection

Volume: 23, Issue: 6, Pages: 101206 - 101206
Published: Jun 1, 2020
Abstract
•Mtb down-modulates TRPV4 expression in macrophages•Trpv4−/− macrophages cannot be activated to drive phagosome maturation and NO production•Trpv4-deficient mice are more resistant to Mtb•TRPV4-positive macrophages in the periphery of human granuloma but not at the center Mycobacterium tuberculosis subverts host immunity to proliferate within host tissues. Non-selective transient receptor potential (TRP) ion channels are involved in host...
Paper Details
Title
Differential Roles of the Calcium Ion Channel TRPV4 in Host Responses to Mycobacterium tuberculosis Early and Late in Infection
Published Date
Jun 1, 2020
Journal
Volume
23
Issue
6
Pages
101206 - 101206
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