Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis
Abstract
We describe a human nasal epithelial (HNE) organoid model derived directly from patient samples that is well-differentiated and recapitulates the airway epithelium, including the expression of cilia, mucins, tight junctions, the cystic fibrosis transmembrane conductance regulator (CFTR), and ionocytes. This model requires few cells compared to airway epithelial monolayer cultures, with multiple outcome measurements depending on the application....
Paper Details
Title
Human Nasal Epithelial Organoids for Therapeutic Development in Cystic Fibrosis
Published Date
May 29, 2020
Journal
Volume
11
Issue
6
Pages
603 - 603
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