The role of FOXOs and autophagy in cancer and metastasis—Implications in therapeutic development
Abstract
Autophagy is a highly conserved intracellular degradation process that plays a crucial role in cell survival and stress reactions as well as in cancer development and metastasis. Autophagy process involves several steps including sequestration, fusion of autophagosomes with lysosomes and degradation. Forkhead box O (FOXO) transcription factors regulate the expression of genes involved in cellular metabolic activity and signaling pathways of...
Paper Details
Title
The role of FOXOs and autophagy in cancer and metastasis—Implications in therapeutic development
Published Date
May 31, 2020
Journal
Volume
40
Issue
6
Pages
2089 - 2113
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