Discovery of lipophilic two‐pore channel agonists

Two‐pore channels (TPCs) have been a hot topic in recent literature. Their involvement in various diseases such as viral infections and cancer is of great interest for drug research. Due to their localization in the endolysosomal system and the lack of cell‐permeable activators, complex techniques were required for studying channel functions. Here, we review the first published lipophilic small‐molecule activators of TPCs. In independent...