Reduction of senescence‐associated beta‐galactosidase activity by vitamin E in human fibroblasts depends on subjects’ age and cell passage number

Cell senescence is due to the permanent cell cycle arrest that occurs as a result of the inherent limited replicative capacity toward the Hayflick limit (replicative senescence), or in response to various stressors (stress‐induced premature senescence, SIPS). With the acquisition of the senescence‐associated secretory phenotype (SASP), cells release several molecules (cytokines, proteases, lipids), and express the senescence‐associated...