A Spore‐Forming Probiotic Supplement Improves the Intestinal Immune Response and Protects the Intestinal Health During Recurrent Clostridioides difficile Colonization in Mice

Background Around 15%–30% of patients develop recurrent Clostridioides difficile infection (CDI) as conventional therapies disrupt protective gut microbiota. We tested if supplementation with a spore‐forming probiotic would protect intestinal health in a mouse model of recurrent CD colonization. Methods Methods: Female CF‐1 mice were exposed to CD spores (4‐log 10 colony‐forming units/10 μL) and then randomly assigned to receive either saline...