An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor
Abstract
Most drugs acting on G-protein-coupled receptors target the orthosteric binding pocket where the native hormone or neurotransmitter binds. There is much interest in finding allosteric ligands for these targets because they modulate physiologic signaling and promise to be more selective than orthosteric ligands. Here we describe a newly developed allosteric modulator of the β2-adrenergic receptor (β2AR), AS408, that binds to the membrane-facing...
Paper Details
Title
An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor
Published Date
Jun 1, 2020
Journal
Volume
16
Issue
7
Pages
749 - 755
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