Population-specific reference panels are crucial for genetic analyses: an example of the CREBRF locus in Native Hawaiians

Volume: 29, Issue: 13, Pages: 2275 - 2284
Published: Jun 3, 2020
Abstract
Statistical imputation applied to genome-wide array data is the most cost-effective approach to complete the catalog of genetic variation in a study population. However, imputed genotypes in underrepresented populations incur greater inaccuracies due to ascertainment bias and a lack of representation among reference individuals, further contributing to the obstacles to study these populations. Here we examined the consequences due to the lack of...
Paper Details
Title
Population-specific reference panels are crucial for genetic analyses: an example of the CREBRF locus in Native Hawaiians
Published Date
Jun 3, 2020
Volume
29
Issue
13
Pages
2275 - 2284
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