Simulating diffusion from a cluster of point sources using propagation integrals

A computational methodology to simulate the diffusion of ions from point sources (e.g., ion channels) is described. The outlined approach computes the ion concentration from a cluster of many ion channels at pre-specified locations as a function of time using the theory of propagation integrals. How the channels’ open/closed states evolve in time does not need to be known at the start of the simulation, but can be updated on-the-fly as the...