Combined inhibition of menin-MLL interaction and TGF-β signaling induces replication of human pancreatic beta cells
Volume: 99, Issue: 5, Pages: 151094 - 151094
Published: Jun 1, 2020
Abstract
Both type 1 and type 2 diabetes are associated with hyperglycemia and loss of functional beta cell mass. Inducing proliferation of preexisting beta cells is an approach to increase the numbers of beta cells. In this study, we examined a panel of selected small molecules for their proliferation-inducing effects on human pancreatic beta cells. Our results demonstrated that a small molecule inhibitor of the menin-MLL interaction (MI-2) and small...
Paper Details
Title
Combined inhibition of menin-MLL interaction and TGF-β signaling induces replication of human pancreatic beta cells
Published Date
Jun 1, 2020
Volume
99
Issue
5
Pages
151094 - 151094
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