An exploratory study of metformin with or without rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic adenocarcinoma

Volume: 11, Issue: 21, Pages: 1929 - 1941
Published: May 26, 2020
Abstract
Metformin combined with the mTOR inhibitor rapamycin showed potential synergistic anti-tumor activity in preclinical studies in pancreatic ductal adenocarcinoma (PDA). This phase 1b study (NCT02048384) was conducted to evaluate the feasibility and activity of metformin +/- rapamycin in the maintenance setting for unselected patients with metastatic PDA (mPDA) treated with chemotherapy.Eligible patients with stable or responding mPDA after ≥ 6...
Paper Details
Title
An exploratory study of metformin with or without rapamycin as maintenance therapy after induction chemotherapy in patients with metastatic pancreatic adenocarcinoma
Published Date
May 26, 2020
Journal
Volume
11
Issue
21
Pages
1929 - 1941
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