Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response
Abstract
The advent of base editors (BEs) holds great potential for correcting pathogenic-related point mutations to treat relevant diseases. However, Cas9 nickase (nCas9)-derived BEs lead to DNA double-strand breaks, which can trigger unwanted DNA damage response (DDR). Here, we show that the original version of catalytically dead Cas12a (dCas12a)-conjugated BEs induce a basal level of DNA breaks and minimally activate DDR proteins, including H2AX, ATM,...
Paper Details
Title
Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response
Published Date
Jun 1, 2020
Journal
Volume
31
Issue
9
Pages
107723 - 107723
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