A Multiplexed Barcodelet Single-Cell RNA-Seq Approach Elucidates Combinatorial Signaling Pathways that Drive ESC Differentiation

Volume: 26, Issue: 6, Pages: 938 - 950.e6
Published: Jun 1, 2020
Abstract
Empirical optimization of stem cell differentiation protocols is time consuming, is laborintensive, and typically does not comprehensively interrogate all relevant signaling pathways. Here we describe barcodelet single-cell RNA sequencing (barRNA-seq), which enables systematic exploration of cellular perturbations by tagging individual cells with RNA barcodelets to identify them on the basis of the treatments they receive. We apply barRNA-seq to...
Paper Details
Title
A Multiplexed Barcodelet Single-Cell RNA-Seq Approach Elucidates Combinatorial Signaling Pathways that Drive ESC Differentiation
Published Date
Jun 1, 2020
Volume
26
Issue
6
Pages
938 - 950.e6
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