Patterns of progression and subsequent management of patients with BRCA1/2 mutated platinum-sensitive recurrent epithelial ovarian cancer (EOC) progressing on olaparib versus placebo: the SOLO2/ENGOT Ov-21 trial (NCT01874353).

6070 Background: Olaparib maintenance is a standard treatment of BRCA1/2 mutated platinum-sensitive recurrent EOC. Despite improvement in PFS, olaparib (O) resistance often occurs and the optimal management of post-olaparib progression remains undefined. Methods: Data of patients who participated in the SOLO-2 trial and progressed were analyzed. Primary objective was to depict the patterns of progression of patients treated with O compared to...