Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity
Abstract
Natural killer (NK) cells are cytotoxic innate lymphoid cells (ILCs) that mediate antiviral and antitumor responses and require the transcriptional regulator Eomesodermin (Eomes) for early development. However, the role of Eomes and its molecular program in mature NK cell biology is unclear. To address this, we develop a tamoxifen-inducible, type-1-ILC-specific (Ncr1-targeted) cre mouse and combine this with Eomes-floxed mice. Eomes deletion...
Paper Details
Title
Stage-Specific Requirement for Eomes in Mature NK Cell Homeostasis and Cytotoxicity
Published Date
Jun 1, 2020
Journal
Volume
31
Issue
9
Pages
107720 - 107720
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