Original paper
Chronotherapy targeting cytokine secretion attenuates collagen-induced arthritis in mice
Abstract
Diurnal variation of symptoms are observed in rheumatoid arthritis, especially in productions of cytokines that show peak concentrations during mid night. In contrast, cytokines of collagen-induced arthritis (CIA) mice increase in daytimes under Mid-light condition. By using chronotherapy, differences in drug efficacies according to administration time of Baricitinib, a wide ranged cytokine blocker, were examined in CIA mice. CIA mice were...
Paper Details
Title
Chronotherapy targeting cytokine secretion attenuates collagen-induced arthritis in mice
Published Date
Jul 1, 2020
Volume
84
Pages
106549 - 106549
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