Functional properties and sequence variation of HTLV-1 p13

Human T cell leukemia virus type-1 (HTLV-1) was the first retrovirus found to cause cancer in humans, but the mechanisms that drive the development of leukemia and other diseases associated with HTLV-1 infection remain to be fully understood. This review describes the functional properties of p13, an 87-amino acid protein coded by HTLV-1 open reading frame II ( orf - II ). p13 is mainly localized in the inner membrane of the mitochondria, where...