Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation
Abstract
The polyglutamine (polyQ) diseases are a group of inherited neurodegenerative diseases that include Huntington’s disease, various spinocerebellar ataxias, spinal and bulbar muscular atrophy, and dentatorubral pallidoluysian atrophy. They are caused by the abnormal expansion of a CAG repeat coding for the polyQ stretch in the causative gene of each disease. The expanded polyQ stretches trigger abnormal β-sheet conformational transition and...
Paper Details
Title
Arginine is a disease modifier for polyQ disease models that stabilizes polyQ protein conformation
Published Date
May 21, 2020
Journal
Volume
143
Issue
6
Pages
1811 - 1825
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