Use of the Win Ratio in Cardiovascular Trials

The purpose of this study was to compare the win ratio (WR) with the corresponding hazard ratios (HRs) and 1/HR. The primary outcome in many cardiovascular trials is a composite that includes nonfatal and fatal events. The time-to-first event analysis gives equal statistical weighting to each component event. The WR, which takes into account the clinical importance and timing of the outcomes, has been suggested as an alternative approach. Cox...