Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity
Abstract
A long-standing problem is how cells that lack one of the highly similar ribosomal proteins (RPs) often display distinct phenotypes. Yeast and other organisms live longer when they lack specific ribosomal proteins, especially of the large 60S subunit of the ribosome. However, longevity is neither associated with the generation time of RP deletion mutants nor with bulk inhibition of protein synthesis. Here, we queried actively dividing RP mutants...
Paper Details
Title
Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity
Published Date
May 20, 2020
Journal
Volume
9
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