T Cell Receptor Engineered Lymphocytes for Cancer Therapy
Abstract
T lymphocytes are capable of specific recognition and elimination of target cells. Physiological antigen recognition is mediated by the T cell receptor (TCR), which is an alpha beta heterodimer comprising the products of randomly rearranged V, D, and J genes. The exquisite specificity and functionality of T cells can be leveraged for cancer therapy: specifically, the adoptive transfer of T cells that express tumor‐reactive TCRs can induce...
Paper Details
Title
T Cell Receptor Engineered Lymphocytes for Cancer Therapy
Published Date
May 20, 2020
Volume
129
Issue
1
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