Preliminary assessment of nanopore-based metagenomic sequencing for the diagnosis of prosthetic joint infection

ObjectivesPathogen identification is crucial for the diagnosis and management of periprosthetic joint infection (PJI). Although culturing methods are the foundation of pathogen detection in PJI, false-negative results often occur. Oxford nanopore sequencing (ONS) is a promising alternative for detecting pathogens and providing information on their antimicrobial resistance (AMR) profiles, without culturing.MethodsTo evaluate the capability of...