It Takes Three Receptors to Raise a B Cell
Abstract
The generation of a diverse antibody repertoire is crucial for the adaptive immune system and is accomplished through sequential V(D)J recombination of loci encoding the immunoglobulin heavy (IgH) and light chain (Igκ and Igλ). The tight regulation and separation of proliferation and differentiation processes during B cell development is crucial for avoiding genomic instability. Previous models identified two receptors, IL-7R and the pre-BCR, as...
Paper Details
Title
It Takes Three Receptors to Raise a B Cell
Published Date
Jul 1, 2020
Journal
Volume
41
Issue
7
Pages
629 - 642
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History