Gene modification strategies for next-generation CAR T cells against solid cancers
Abstract
Immunotherapies have become the backbone of cancer treatment. Among them, chimeric antigen receptor (CAR) T cells have demonstrated great success in the treatment of hematological malignancies. However, CAR T therapy against solid tumors is less effective. Antigen targeting; an immunosuppressive tumor microenvironment (TME); and the infiltration, proliferation, and persistence of CAR T cells are the predominant barriers preventing the extension...
Paper Details
Title
Gene modification strategies for next-generation CAR T cells against solid cancers
Published Date
May 18, 2020
Volume
13
Issue
1
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