Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type C
Abstract
Niemann-Pick disease type C (NPC) is a rare lysosomal storage disease caused by mutations in either the NPC1 or NPC2 genes. Mutations in the NPC1 gene lead to the majority of clinical cases (95%); however, the function of NPC1 remains unknown. To gain further insights into the biology of NPC1, we took advantage of the homology between the human NPC1 protein and its yeast orthologue, Niemann-Pick C-related protein 1 (Ncr1). We recreated the NCR1...
Paper Details
Title
Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type C
Published Date
Jun 2, 2020
Journal
Volume
3
Issue
7
Pages
e201800253 - e201800253
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