Original paper

Cost-effective generation of A-to-G mutant mice by zygote electroporation of adenine base editor ribonucleoproteins

Volume: 47, Issue: 6, Pages: 337 - 340
Published: Jun 1, 2020
Abstract
Prime editor (PE), a new genome editing tool, can generate all 12 possible base-to-base conversions, insertion, and deletion of short fragment DNA. PE has the potential to correct the majority of known human genetic disease-related mutations. Adeno-associated viruses (AAVs), the safe vector widely used in clinics, are not capable of delivering PE (∼6.3 kb) in a single vector because of the limited loading capacity (∼4.8 kb). To accommodate the...
Paper Details
Title
Cost-effective generation of A-to-G mutant mice by zygote electroporation of adenine base editor ribonucleoproteins
Published Date
Jun 1, 2020
Volume
47
Issue
6
Pages
337 - 340
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