Massively parallel assessment of human variants with base editor screens

Abstract
Understanding the functional consequences of single-nucleotide variants is critical to uncovering the genetic underpinnings of diseases, but technologies to characterize variants are limiting. Here we leverage CRISPR-Cas9 cytosine base editors in pooled screens to scalably assay variants at endogenous loci in mammalian cells. We benchmark the performance of base editors in positive and negative selection screens and identify known...
Paper Details
Title
Massively parallel assessment of human variants with base editor screens
Published Date
May 17, 2020
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