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Whole-Blood Resuscitation of Injured Patients: Innovating from the Past

Published on May 13, 2020in JAMA Surgery10.668
· DOI :10.1001/JAMASURG.2020.0811
Christine M. Leeper9
Estimated H-index: 9
(University of Pittsburgh),
Mark H. Yazer30
Estimated H-index: 30
(University of Pittsburgh),
Matthew D. Neal27
Estimated H-index: 27
(University of Pittsburgh)
Abstract
  • References (7)
  • Citations (0)
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References7
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ABSTRACTPurposeFollowing US military implementation of a cold-stored whole blood program, several US trauma centers have begun incorporating uncrossmatched, group O cold-stored whole blood into civilian trauma resuscitation. We set out to evaluate the safety profile, transfusion reactions events, an
7 CitationsSource
#1Francis X. Guyette (University of Pittsburgh)H-Index: 27
#2Jason L. Sperry (University of Pittsburgh)H-Index: 41
Last. Joshua B. BrownH-Index: 21
view all 12 authors...
MiniHemorrhage is the primary cause of preventable trauma death. Secondary analyses of scene patients from the PAMPer trial demonstrated that prehospital packed red blood cell and plasma had the greatest reduction in 30-day mortality compared with crystalloid-only resuscitation. Patients with hemorr
10 CitationsSource
#1Caroline S. Zhu (University of Texas Health Science Center at San Antonio)H-Index: 3
#2Douglas M. Pokorny (University of Texas Health Science Center at San Antonio)H-Index: 2
Last. Donald H. Jenkins (University of Texas Health Science Center at San Antonio)H-Index: 27
view all 15 authors...
BACKGROUND: Despite countless advancements in trauma care a survivability gap still exists in the prehospital setting. Military studies clearly identify hemorrhage as the leading cause of potentially survivable prehospital death. Shifting resuscitation from the hospital to the point of injury has shown great promise in decreasing mortality among the severely injured. MATERIALS AND METHODS: Our regional trauma network (Southwest Texas Regional Advisory Council) developed and implemented a multiph...
3 CitationsSource
#1Christine M. Leeper (University of Pittsburgh)H-Index: 9
#2Mark H. Yazer (University of Pittsburgh)H-Index: 30
Last. Barbara A. Gaines (University of Pittsburgh)H-Index: 23
view all 6 authors...
8 CitationsSource
Abstract : Formulation of a medical preparedness plan for treating severely bleeding casualties during naval deployment is a significant challenge because of territory covered during most missions. The aim of this study was to evaluate the concept of walking blood bank as a supportable plan for supplying safe blood and blood products. In 2013, the Royal Norwegian Navy conducted antipiracy operations from a frigate, beginning in the Gulf of Aden and ending in the Indian Ocean. Crews were on 24-ho...
32 CitationsSource
#1Heather F. Pidcoke (UTSA: University of Texas at San Antonio)H-Index: 19
#2Steve J. McFaul (UTSA: University of Texas at San Antonio)H-Index: 2
Last. Andrew P. Cap (UTSA: University of Texas at San Antonio)H-Index: 31
view all 17 authors...
Abstract : BACKGROUND: Whole blood (WB) has been used in combat since World War I as it is readily available and replaces every element of shed blood. Component therapy has become standard; however, recent military successes with WB resuscitation have revived the debate regarding wider WB use. Characterization of optimal WB storage is needed. We hypothesized that refrigeration preserves WB function and that a pathogen reduction technology (PRT) based on riboflavin and ultraviolet light has no de...
106 CitationsSource
#1David R. Jobes (UPenn: University of Pennsylvania)H-Index: 24
#2Yanika Wolfe (UPenn: University of Pennsylvania)H-Index: 2
Last. X. Long Zheng (UPenn: University of Pennsylvania)H-Index: 25
view all 7 authors...
Background The hemostatic property of “fresh” whole blood (WB) has been observed in military application and cardiac surgery and is associated with reduced blood loss, transfusion requirements, and donor exposures. The time from donation to transfusion defining “fresh” has not been systematically studied. We undertook an in vitro study of coagulation properties of refrigerated WB stored for 31 days.
57 CitationsSource
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