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The burden of productivity loss of U.S. commercially insured patients diagnosed with Dupuytren's disease undergoing collagenase versus fasciectomy treatment.

Published on May 15, 2020in Expert Review of Pharmacoeconomics & Outcomes Research1.828
· DOI :10.1080/14737167.2020.1770085
Abstract
Background: We conducted a comparative assessment of the productivity loss associated with the two different treatment options for Dupuytren’s disease: collagenase and fasciectomy.Methods: The retr...
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References30
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#1Nels D. Leafblad (UR: University of Rochester)H-Index: 1
#2Eric R. Wagner (UR: University of Rochester)H-Index: 18
Last. Marco Rizzo (UR: University of Rochester)
view all 8 authors...
Purpose The aims of our study were to evaluate the rates and predictors of reinterventions and direct costs of 3 common treatments of Dupuytren contractures—needle aponeurotomy, collagenase injection, and surgical fasciectomy. Methods A retrospective review identified 848 interventions for Dupuytren contracture in 350 patients treated by a single surgeon from 2005 to 2016. The treatments included needle aponeurotomy (NA) (n = 444), collagenase injection (n = 272), and open fasciectomy (n = 132)....
2 CitationsSource
#1Christina Turesson (Linköping University)H-Index: 2
#2Joanna Kvist (KI: Karolinska Institutet)H-Index: 27
Last. Barbro Krevers (Linköping University)H-Index: 18
view all 3 authors...
Abstract Study Design Qualitative descriptive. Introduction Dupuytren's disease (DD) is a chronic hand condition causing impairment in hand function. Research describing persons' experiences of living with DD is limited. Understanding the subjective experience of illness is valuable for planning and implementing health-care services. Purpose of the Study To explore experiences among men living with an impaired hand function due to DD and the consequences of the disease for daily activities. Meth...
1 CitationsSource
#1E. Soreide (UR: University of Rochester)H-Index: 1
#2M. Hassan Murad (Mayo Clinic)H-Index: 97
Last. Sanjeev Kakar (UR: University of Rochester)H-Index: 15
view all 8 authors...
Aims Dupuytren’s contracture is a benign, myoproliferative condition affecting the palmar fascia that results in progressive contractures of the fingers. Despite increased knowledge of the cellular...
25 CitationsSource
: Dupuytren disease (DD) is a benign, fibroproliferative disease of unknown cause. The disease predominantly affects the palms of the hands, causing permanent digital contracture of affected digits. DD is a late-onset disease and is often progressive, irreversible, and bilateral. The disease has a significant impact on the health care economy. The mainstay of treatment of DD is surgical excision of diseased palmar fascia. There is evidence of genetic susceptibility. This article introduces the e...
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#1Melina Dritsaki (University of Oxford)H-Index: 9
#2Oliver Rivero-Arias (University of Oxford)H-Index: 24
Last. Jagdeep Nanchahal (University of Oxford)H-Index: 31
view all 5 authors...
Dupuytren’s disease (DD) is a common and progressive, fibroproliferative disorder of the palmar and digital fascia of the hand. Various treatments have been recommended for advanced disease or to retard progression of early disease and to prevent deterioration of the finger contracture and quality of life. Recent studies have tried to evaluate the clinical and cost-effectiveness of therapies for DD, but there is currently no systematic assessment and appraisal of the economic evaluations. A syst...
1 CitationsSource
#1Verena WijnenH-Index: 1
#2Frank BuntinxH-Index: 55
Last. Ilse DegreefH-Index: 18
view all 5 authors...
: In this report, a possible association between Dupuytren's disease (DD) and other health problems was investigated. The health problems included in this study are : cardiac ischemia, hypertension, hyper-lipidemia, diabetes mellitus, epilepsy, gout, rheumatoid arthritis, malignancy, asthma and COPD. The data of 725 patients with DD were collected from -Intego, a database including all morbidity presented to the General Practitioners (GPs) in Flanders. The control group of 2900 age and sex match...
1 Citations
#1Clayton A. Peimer (MSU: Michigan State University)H-Index: 23
#2Philip E. Blazar (Brigham and Women's Hospital)H-Index: 24
Last. Tommy Lindau (Royal Derby Hospital)H-Index: 14
view all 6 authors...
Purpose Collagenase Option for Reduction of Dupuytren Long-Term Evaluation of Safety Study was a 5-year noninterventional follow-up study to determine long-term efficacy and safety of collagenase clostridium histolyticum (CCH) treatment for Dupuytren contracture. Methods Patients from previous CCH clinical studies were eligible. Enrolled patients were evaluated annually for contracture and safety at 2, 3, 4, and 5 years after their first injection (0.58 mg) of CCH. In successfully treated joints...
79 CitationsSource
#1Mary E. Charlson (Cornell University)H-Index: 57
#2Martin T. Wells (Cornell University)H-Index: 35
Last. Celia ShmuklerH-Index: 7
view all 5 authors...
Background Reducing health care costs requires the ability to identify patients most likely to incur high costs. Our objective was to evaluate the ability of the Charlson comorbidity score to predict the individuals who would incur high costs in the subsequent year and to contrast its predictive ability with other commonly used predictors. Methods We contrasted the prior year Charlson comorbidity index, costs, Diagnostic Cost Group (DCG) and hospitalization as predictors of subsequent year costs...
67 CitationsSource
Learning Objectives:After studying this article, the participant should be able to: 1. Describe features and clinical importance of Dupuytren diathesis. 2. Explain the difference between the new definition of recurrence used in collagenase studies compared with prior definitions of recurrence. 3. Co
25 CitationsSource
#1Robert Grant (St George's, University of London)H-Index: 21
Odds ratios are a necessary evil in medical research; although used as a measure of effect size from logistic regressions and case-control studies, they are poorly understood. This paper provides practical advice for authors and readers on converting odds ratios to relative risks
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