TRPV4 Antagonism Prevents Mechanically Induced Myotonia
Abstract
Objective Myotonia is caused by involuntary firing of skeletal muscle action potentials and causes debilitating stiffness. Current treatments are insufficiently efficacious and associated with side effects. Myotonia can be triggered by voluntary movement (electrically induced myotonia) or percussion (mechanically induced myotonia). Whether distinct molecular mechanisms underlie these triggers is unknown. Our goal was to identify ion channels...
Paper Details
Title
Published Date
Jun 22, 2020
Journal
Volume
88
Issue
2
Pages
297 - 308
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