Perspectives given by structural connectivity bridge the gap between structure and function.

Published on May 15, 2020in Brain Structure & Function3.622
· DOI :10.1007/S00429-020-02080-Z
Hiromasa Takemura8
Estimated H-index: 8
Michel Thiebaut de Schotten36
Estimated H-index: 36
  • References (41)
  • Citations (0)
📖 Papers frequently viewed together
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Alexander Woodward (Woodward, Inc.)H-Index: 1
#1Alexander WoodwardH-Index: 1
Last. Tetsuo YamamoriH-Index: 26
view all 11 authors...
We describe our connectomics pipeline for processing anterograde tracer injection data for the brain of the common marmoset (Callithrix jacchus). Brain sections were imaged using a batch slide scanner (NanoZoomer 2.0-HT) and we used artificial intelligence to precisely segment the tracer signal from the background in the fluorescence images. The shape of each brain was reconstructed by reference to a block-face and all data were mapped into a common 3D brain space with atlas and 2D cortical flat...
1 CitationsSource
#1Susie Y. Huang (Harvard University)H-Index: 12
#2Qiyuan Tian (Harvard University)H-Index: 8
Last. Aapo Nummenmaa (Harvard University)H-Index: 19
view all 12 authors...
Axon diameter and density are important microstructural metrics that offer valuable insight into the structural organization of white matter throughout the human brain. We report the systematic acquisition and analysis of a comprehensive diffusion MRI data set acquired with 300 mT/m maximum gradient strength in a cohort of 20 healthy human subjects that yields distinct and consistent patterns of axon diameter index in white matter tracts of arbitrary orientation. We use a straightforward, previo...
3 CitationsSource
#1Brian Rooks (URMC: University of Rochester Medical Center)H-Index: 3
#2Mia Anthony (UR: University of Rochester)H-Index: 1
Last. Feng LinH-Index: 12
view all 8 authors...
Making reasonable decisions related to financial and health scenarios is a crucial capacity that can be difficult for older adults to maintain as they age, yet few studies examine neurocognitive factors that are generalizable to different types of everyday decision-making capacity. Here we propose an innovative approach, based on individual risk-taking preference, to identify neural profiles that may help predict older adults’ everyday decision-making capacity. Using performance and cognitive ar...
1 CitationsSource
#1Quinn Andre (U of C: University of Calgary)
#2Bryce L. Geeraert (U of C: University of Calgary)H-Index: 3
Last. Catherine LebelH-Index: 24
view all 3 authors...
Mental health problems often emerge in adolescence and are associated with reduced gray matter thickness or volume in the prefrontal cortex (PFC) and limbic system and reduced fractional anisotropy (FA) and increased mean diffusivity (MD) of white matter linking these regions. However, few studies have investigated whether internalizing and externalizing behavior are associated with brain structure in children and adolescents without mental health disorders, which is important for understanding ...
2 CitationsSource
#1Szabolcs David (UU: Utrecht University)H-Index: 6
#2Lieke Heesink (University of Chichester)H-Index: 5
Last. Alexander Leemans (UU: Utrecht University)H-Index: 49
view all 7 authors...
Aggression after military deployment is a common occurrence in veterans. Neurobiological research has shown that aggression is associated with a dysfunction in a network connecting brain regions implicated in threat processing and emotion regulation. However, aggression may also be related to deficits in networks underlying communication and social cognition. The uncinate and arcuate fasciculi are integral to these networks, thus studying potential abnormalities in these white matter connections...
1 CitationsSource
#1Kenichi Oishi (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 29
#2Susumu Mori (ICSCI: Kennedy Krieger Institute)H-Index: 82
Last. Frederick Lenz (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 51
view all 4 authors...
The cortico-basal ganglia-thalamo-cortical feedback loops that consist of distinct white matter pathways are important for understanding in vivo imaging studies of functional and anatomical connectivity, and for localizing subthalamic white matter structures in surgical approaches for movement disorders, such as Parkinson's disease. Connectomic analysis in animals has identified fiber connections between the basal ganglia and thalamus, which pass through the fields of Forel, where other fiber pa...
1 CitationsSource
#1R. Jarrett Rushmore (BU: Boston University)H-Index: 7
#2Sylvain Bouix (Brigham and Women's Hospital)H-Index: 37
Last. Nikos Makris (BU: Boston University)H-Index: 76
view all 6 authors...
The structure of the human brain has been studied extensively. Despite all the knowledge accrued, direct information about connections, from origin to termination, in the human brain is extremely limited. Yet there is a widespread misperception that human connectional neuroanatomy is well-established and validated. In this article, we consider what is known directly about human structural and connectional neuroanatomy. Information on neuroanatomical connections in the human brain is in fact deri...
1 CitationsSource
#1Takaaki Kaneko (Primate Research Institute)H-Index: 4
#2Hiromasa Takemura (National Institute of Information and Communications Technology)H-Index: 8
Last. David A. Leopold (NIH: National Institutes of Health)H-Index: 45
view all 6 authors...
The primate brain contains a large number of interconnected visual areas, whose spatial organization and intracortical projections show a high level of conservation across species. One fiber pathway of recent interest is the vertical occipital fasciculus (VOF), which is thought to support communication between dorsal and ventral visual areas in the occipital lobe. A recent comparative diffusion MRI (dMRI) study reported that the VOF in the macaque brain bears a similar topology to that of the hu...
1 CitationsSource
#1Davy Charles Vanderweyen (Université de Sherbrooke)H-Index: 1
#2Guillaume Theaud (Université de Sherbrooke)H-Index: 2
Last. David Fortin (Université de Sherbrooke)H-Index: 25
view all 7 authors...
Primary brain tumors are notoriously hard to resect surgically. Due to their infiltrative nature, finding the optimal resection boundary without damaging healthy tissue can be challenging. One potential tool to help make this decision is diffusion-weighted magnetic resonance imaging (dMRI) tractography. dMRI exploits the diffusion of water molecule along axons to generate a 3D modelization of the white matter bundles in the brain. This feature is particularly useful to visualize how a tumor affe...
1 CitationsSource
#1G. Blazquez Freches (Radboud University Nijmegen)H-Index: 1
Last. Rogier B. MarsH-Index: 40
view all 6 authors...
To establish the link between structure and function of any large area of the neocortex, it is helpful to identify its principles of organisation. One way to establish such principles is to investigate how differences in whole-brain connectivity are structured across the area. Here, we use Laplacian eigenmaps on diffusion MRI tractography data to investigate the organisational principles of the human temporal association cortex. We identify three overlapping gradients of connectivity that are, f...
5 CitationsSource
Cited By0