Emerging Targets for Cardiovascular Disease Prevention in Diabetes

‘Reverse translation’ harnesses genetic information or data from human biosamples as the primary discovery tool. This approach, when combined with mechanistic studies in animal model systems, has provided important insights into emerging CVD treatment strategies. Increased catabolism of triglyceride-rich lipoproteins through activation of lipoprotein lipase (LPL) appears to prevent both CVD and T2DM. This pathway includes APOC3,...