The effect of general anaesthetics on brain lactate release
Abstract
The effects of anaesthetic agents on brain energy metabolism may explain their shared neurophysiological actions but remain poorly understood. The brain lactate shuttle hypothesis proposes that lactate, provided by astrocytes, is an important neuronal energy substrate. Here we tested the hypothesis that anaesthetic agents impair the brain lactate shuttle by interfering with astrocytic glycolysis. Lactate biosensors were used to record changes in...
Paper Details
Title
The effect of general anaesthetics on brain lactate release
Published Date
Aug 1, 2020
Volume
881
Pages
173188 - 173188
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