Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation
Abstract
The PIDDosome is a multiprotein complex that drives activation of caspase-2, an endopeptidase originally implicated in apoptosis. Yet, unlike other caspases involved in cell death and inflammation, caspase-2 seems to exert additional versatile functions unrelated to cell death. These emerging roles range from control of transcription factor activity to ploidy surveillance. Thus, caspase-2 and the PIDDosome act as a critical regulatory unit...
Paper Details
Title
Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation
Published Date
May 15, 2020
Journal
Volume
27
Issue
7
Pages
2037 - 2047
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