Reduced purine biosynthesis in humans after their divergence from Neandertals
Abstract
We analyze the metabolomes of humans, chimpanzees and macaques in muscle, kidney and three different regions of the brain. Whereas several compounds in amino acid metabolism occur at either higher or lower concentrations in humans than in the other primates, metabolites in oxidative phosphorylation and purine biosynthesis are consistently present in lower concentrations in the brains of humans. In particular, metabolites downstream of...
Paper Details
Title
Reduced purine biosynthesis in humans after their divergence from Neandertals
Published Date
May 13, 2020
Journal
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