Assessing White Matter Pathology in Early-Stage Parkinson Disease Using Diffusion MRI: A Systematic Review

Structural brain white matter (WM) changes such as axonal caliber, density, myelination, and orientation along with WM-dependent structural connectivity may be impacted early in Parkinson’s disease (PD). Diffusion MRI (dMRI) has been used extensively to understand such pathological WM changes, and the focus of this systematic review is to understand both the methods utilized and their corresponding results in the context of early-stage PD....