Senescent Fibroblast–Derived GDF15 Induces Skin Pigmentation
Volume: 140, Issue: 12, Pages: 2478 - 2486.e4
Published: Dec 1, 2020
Abstract
Senescent fibroblasts play a role in aging pigmentation. In this study, we found that GDF15 expression levels are increased in UV-irradiated senescent fibroblasts and photoaged hyperpigmented skin. To investigate the effects of GDF15 on melanogenesis, normal human melanocytes were cocultured with fibroblasts infected with the GDF15 lentivirus or GDF15 short hairpin RNA. It was found that GDF15 stimulates melanogenesis in melanocytes through...
Paper Details
Title
Senescent Fibroblast–Derived GDF15 Induces Skin Pigmentation
Published Date
Dec 1, 2020
Volume
140
Issue
12
Pages
2478 - 2486.e4
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