Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions
Abstract
Pseudomonas aeruginosa infection elicits the production of cytotoxic amyloids from lung endothelium, yet molecular mechanisms of host-pathogen interaction that underlie the amyloid production are not well understood. We examined the importance of type III secretion system (T3SS) effectors in the production of cytotoxic amyloids. P aeruginosa possessing a functional T3SS and effectors induced the production and release of cytotoxic amyloids from...
Paper Details
Title
Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions
Published Date
May 15, 2020
Journal
Volume
34
Issue
7
Pages
9156 - 9179
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