Praziquantel-loaded solid lipid nanoparticles: Production, physicochemical characterization, release profile, cytotoxicity and in vitro activity against Schistosoma mansoni

Praziquantel (PZQ) is an anthelmintic drug, being the first choice for the treatment of schistosomiasis. Its high hydrophobic character and its low water solubility are the main limitations to the development of liquid formulations for the oral administration of the drug. The aim of this work was to develop Solid Lipid Nanoparticles (SLN) for the loading of PZQ for the treatment of S. mansoni infections. PZQ-SLN were produced by hot high shear...