Localisation analysis of nerves in the mouse pancreas reveals the sites of highest nerve density and nociceptive innervation

Background Neuropathy and neuro‐inflammation drive the severe pain and disease progression in human chronic pancreatitis and pancreatic cancer. Mice, especially genetically induced‐mouse models, have been increasingly utilized in mechanistic research on pancreatic neuropathy, but the normal “peripheral neurobiology” of the mouse pancreas has not yet been critically compared to human pancreas. Methods We introduced a standardized...