Circadian-Like Rhythmicity of Extracellular Brain Glutamate in Epilepsy

Seizures often exhibit striking circadian-like (approximately 24-hour) rhythms. While chronotherapy has shown promise in treating epilepsy, it is not widely used, in part because the patterns of seizure rhythmicity vary considerably among patients and types of epilepsy. A better understanding of the mechanisms underlying rhythmicity in epilepsy could be expected to result in more effective approaches which can be tailored to each individual...