High efficiency CHO cell display-based antibody maturation
Abstract
Previously, we developed a CHO cell display-based antibody maturation procedure in which an antibody (or other protein) gene of interest was induced to mutate by activation-induced cytidine deaminase (AID) and then form a library by simply proliferating the CHO cells in culture. In this study, we further improved the efficiency of this maturation system by reengineering AID, and optimizing the nucleic acid sequence of the target antibody gene...
Paper Details
Title
High efficiency CHO cell display-based antibody maturation
Published Date
May 15, 2020
Journal
Volume
10
Issue
1
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